Guitar Hero: World Tour se skládá výhradně z nahrávek největších klasických a moderních rockových kapel všech dob včetně Val Halen, Linkin Park, Eagles, Sublime a mnoha dalších. Ve hře bude k dispozici více stahovatelné hudby než kdykoli předtím. Začínající rockové hvězdy budou mít rovněž tvůrčí oprávnění, aby si mohly vše plně přizpůsobit od svého vzhledu a nástrojů až k logu kapely a k obalům alba.

"Beautiful Disaster" -- 311
"The Kill" -- 30 Seconds to Mars
"Too Much Too Young" -- Airbourne
"Ramblin Man" -- The Allman Brothers Band
"Good God" -- Anouk
"Never Too Late" -- The Answer
"One Armed Scissor" -- At The Drive-In
"No Sleep Till Brooklyn" -- Beastie Boys
"Hail to the Freaks" -- Beatsteaks
"Rebel Yell" -- Billy Idol
"Stillborn" -- Black Label Society
"Weapon of Choice" -- Black Rebel Motorcycle Club
"Dammit" -- blink-182
"One Way or Another" -- Blondie
"Hollywood Nights" -- Bob Seger & The Silver Bullet Band
"Livin' On A Prayer" -- Bon Jovi
"Scream Aim Fire" -- Bullet For My Valentine
"Shiver" -- Coldplay
"Up Around The Bend" -- Creedence Clearwater Revival
"Love Removal Machine" -- The Cult
"Feel the Pain" -- Dinosaur Jr.
"Love Me Two Times" -- The Doors
"Pull Me Under" -- Dream Theater
"Hotel California" -- The Eagles
"Aggro" -- The Enemy
"Hey Man, Nice Shot" -- Filter
"Go Your Own Way" -- Fleetwood Mac
"Everlong" -- Foo Fighters
"American Woman" -- The Guess Who
"You're Gonna Say Yeah!" -- Hush Puppies
"Obstacle 1" -- Interpol
"Mountain Song" -- Jane's Addiction
"Purple Haze (Live)" -- Jimi Hendrix
"The Wind Cries Mary" -- Jimi Hendrix
"The Middle" -- Jimmy Eat World
"Satch Boogie" -- Joe Satriani
"Vinternoll2" -- Kent
"Freak on a Leash" -- Korn
"Our Truth" -- Lacuna Coil
"Are You Gonna Go My Way" -- Lenny Kravitz
"What I've Done" -- Linkin Park
"Prisoner of Society" -- The Living End
"La Bamba" -- Los Lobos
"Rooftops (A Liberation Broadcast)" -- Lost Prophets
"Sweet Home Alabama (Live)" -- Lynyrd Skynyrd
"L'Via L'Viaquez" -- Mars Volta
"Kick Out The Jams" -- MC5's Wayne Kramer
"Trapped Under Ice" -- Metallica
"Beat It" -- Michael Jackson
"Float On" -- Modest Mouse
"Overkill" -- Motörhead
"Assassin" -- Muse
"Nuvole e Lenzuola" -- Negramaro
"About a Girl (Unplugged)" -- Nirvana
"Spiderwebs" -- No Doubt
"Soul Doubt" -- NOFX
"Some Might Say" -- Oasis
"Crazy Train" -- Ozzy Osbourne
"Mr. Crowley" -- Ozzy Osbourne
"Misery Business" -- Paramore
"Heartbreaker" -- Pat Benatar
"The One I Love" -- R.E.M.
"Escuela De Calor" -- Radio Futura
"Re-Education Through Labor" -- Rise Against
"Pretty Vacant" -- Sex Pistols
"Lazy Eye" -- Silversun Pickups
"Today" -- Smashing Pumpkins
"Do It Again" -- Steely Dan
"The Joker" -- Steve Miller Band
"Demolition Man (Live)" -- Sting
"Love Spreads" -- The Stone Roses
"Toy Boy" -- Stuck In The Sound
"Santeria" -- Sublime
"Eye of the Tiger" -- Survivor
"B.Y.O.B." -- System of a Down
"Stranglehold" -- Ted Nugent
Ted Nugent's Original Guitar Duel Recording
"Monsoon" -- Tokio Hotel
"Parabola" -- Tool
"Schism" -- Tool
"Vicarious" -- Tool
"Antisocial" -- Trust
"Hot For Teacher" -- Van Halen
"On The Road Again" -- Willie Nelson
"Band on the Run" -- Wings
Zakk Wylde's Original Guitar Duel Recording